MRI radiomic analysis in radiotherapy of brain metastases

Duration: Since 2022

Abstract

Stereotactic radiotherapy (SRT) is the current standard of care for brain oligometastases. SRT is characterized by a high dose delivered in less than five fractions and with a steep dose gradient to surrounding healthy brain tissue. However, follow-up MRI is often ambiguous due to the frequent presence of treatment-related changes such as radiation necrosis or pseudoprogression. Importantly, a valid assessment of local control is essential for the indication of further systemic therapy such as modern targeted therapy or immunotherapy.

The practice of medicine is changing with the development of new Artificial Intelligence methods of machine learning. Nowadays, radiology, as well as radiotherapy, strongly relies on the help of computers, especially when dealing with large 3D image data. Finding important image content that is often hidden to the naked eye is called radiomics, which means extraction of image or object features (descriptors) that quantitatively characterize the image or its parts in mathematical terms.

It is reasonably assumed that there will be a significant increase of incidence of patients with brain metastases indicated to SRT. Exact and valid evaluation of follow-up MRI after targeted SRT represents an unmet clinical need which is increasingly important for the individual patient in respect to increasing possibilities of modern systemic treatment of disseminated disease. Moreover, due to the limited availability of advanced MRI or PET/CT methods for brain imaging for further imaging of equivocal findings on standard contrast enhanced structural MRI, the development of other approaches is recommended.

The aim of presented study is to develop a radiomic model for the evaluation of contrast enhanced structural brain MRI after SRT of brain metastases in terms of differential diagnosis of radiotherapy-related changes and true progression in order to increase sensitivity and specificity of MRI evaluation. Specifically, a retrospective cohort of patients treated by stereotactic radiotherapy for brain metastases will be created for subsequent development of radiomic model. Prospective cohort with regular standardized follow-up will serve for validation.

Participating groups and people

Masaryk Memorial Cancer Institute

Brno, CZ

Key staff
Tomáš Kazda, Vít Nováček

Centre for Biomedical Image Analysis

Faculty of Informatics, Masaryk University, Brno, CZ

Key staff
Michal Kozubek, Karel Štěpka, David Wiesner

Department of Machine Learning and Data Processing

Faculty of Informatics, Masaryk University, Brno, CZ

Key staff
Tomáš Brázdil

Funding

5/2022 – 12/2025: Czech Health Research Council, NU22-03-00159, Structural MRI radiomic analysis for differential diagnosis of radiation injury and true progression after stereotactic radiotherapy of brain metastases

More information

Example of processed image data

The figure shows the evolution for non small cell lung cancer patient with a solitary frontal lobe metastasis who was irradiated by fractionated stereotactic radiotherapy 3x8 Gy (9 Gy to central part of metastasis as a controlled dose gradient) during March 2020. After small regression and stabilization, equivocal increase of contrast enhancing lesion was described on two following MRI 3/2021 and 5/2021. No pathological avidity was described on 18FDG PET (6/2021) and the patient may continue with the administration of current targeted therapy.

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