AI methods in digital pathology

Duration: Since 2020

Abstract

We develop methods for cancer diagnosis using AI models trained on data from digital pathology. We concentrate on diagnosing carcinoma in surgery samples and biopsies, which represents a significant part of the workload in clinical histopathology. Our main aim is to develop semi-automated systems integrated into pathologists' workflow to make the diagnosis faster and, possibly, more reliable while understanding how the AI systems work and what are their limits. As the primary source of data, we consider whole-slide microscopic images of tissue and develop methods based on various machine learning techniques for recognizing characteristic tumor patterns.

Since our main aim is to obtain reliable systems ready for routine use, we concentrate on extensive evaluation and testing and exploring various interpretability methods built into or applied on AI systems. We aim for reproducible systems that can undergo certifications necessary for clinical practice in the future and thus we incorporate provenance generation into the AI pipelines and feed experience with this process into provenance standardization activities (e.g., contributing to ISO standards development).

Participating groups and people

No description

Masaryk Memorial Cancer Institute

Brno, CZ

Key staff
Rudolf Nenutil

No description

​Department of Machine Learning and Data Processing​

Faculty of Informatics, Masaryk University, Brno, CZ

Key staff
Tomáš Brázdil

No description

Institute of Computer Science
Masaryk University, Brno, CZ

Key staff
Petr Holub

International collaboration

No description

Diagnostic and Research Institute of Pathology
Medical University of Graz, Austria

Key staff
Heimo Müller

No description

Competence Center for Artificial Intelligence and Machine Learning
Technical University of Berlin, Germany

Key staff
Christian Geissler

Funding

11/2022 – 10/2025: EU TWINNING BioMedAI

More information

Example of processed image data

The figure shows an example of tissue stained with hematoxylin-eosin with rough manual annotation of pathological region (cyan). The computer splits the tissue into square regions and, for each region, it assesses the probability that the region contains pathological content (saturation of yellow).

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